Mitosis is a highly regulated process that allows equal distribution of the genetic material to the daughter cells. The mitotic spindle is a bipolar structure composed of highly dynamic microtubule polymers. The formation and maintenance of the bipolar spindle and chromosome alignement and segregation during mitosis are critical to maintaining genomic integrity. Several of the mitotic microtubule-associated proteins are key to controlling these processes and therefore prime candidates as anti-cancer drug targets.
Our goal is to define how
- Microtubule motors transport and cooperate with their cargos to ultimately build the mitotic spindle and align chromosomes.
- Chromosomes move along the spindle and segregate.
We use a holistic mechanistic approach ranging from structural biology to single molecule imaging and quantitative cell biology.