Publications

Click on coloured title for link to the paper.

 

Legal  T., Hayward D., Gluszek-Kustusz  A., Blackburn  EA., Spanos  C., Rappsilber  J., Gruneberg  U., Welburn  JPI. The C-terminal helix of BubR1 is essential for CENP-E-dependent chromosome alignment. JCS (2020), In press.

 

Craske B. Welburn  JPI. Leaving no-one behind: how CENP-E facilitates chromosome alignment. Essays in Biochemistry. 2020, In Press.

 

Nehlig A., Seiler C., Steblyanko Y., Dingli F., Arras G., Loew D.,  Welburn J., Prigent C., Barisic M., Nahmias C. Aurora kinase A-dependent ATIP3-Kif2a-Dda3 complex maintains metaphase spindle length. Cellular and Molecular Life Sciences. In press.

 

Bergendahl LT., Gerasimavicius L., Miles J., Macdonald L., Wells JN.,  Welburn JPI., Marsh JA. The role of protein complexes in human genetic disease (2019). Protein science.

 

 

McHugh  T, Zou  J, Volkov V,  Bertin A, Talapatra SK, Rappsilber J, Dogterom M, Welburn JPI. The depolymerase activity of MCAK shows a graded response to Aurora B kinase phosphorylation through allosteric regulation (2019). JCS. 

 


 

Deretic J., Kerr A. and Welburn JPI. A rapid computational approach identifies SPICE1 as an Aurora kinase substrate.  (2018). MBOC.


 

Friel C and Welburn JPI . Part list for a microtubule depolymerizing kinesin (2018). Biochemical Society Transactions.


 

McHugh T., Gluszek-Kustusz  A., Welburn JPI. Kinesin-8 motor Kif18b tethering to microtubule ends is a requirement for spindle positioning. (2018). JCB. 217:7.

 


Welburn JPI and Jeyaprakash AA. Mechanisms of mitotic kinase regulation: a structural perspective. (2018). Frontiers in Cell and Developmental biology. 6:6. 


McHugh T, Welburn JPI. Dynein at kinetochores: making the connection. (2017). JCB. 216(4): 855-857.


Gigant E., Stefanutti M, LabandK, Gluszek-Kustusz  A., Edwards F., Maton  G.,Lacroix B, Canman JC., WelburnJPI , DumontJ. Inhibition of ectopic microtubule assembly by the kinesin-13 KLP-7MCAKprevents oocyte aneuploidy. (2017) Development.


Legal T., Zou J., Sochaj A., Rappsilber J., Welburn JPI. Molecular architecture of the Dam1 complex-microtubule interaction. (2016). Open Biology. DOI: 10.1098.


Kajtez J., Solomatina A., Novak M., Vukušić K., Polak B., Rüdiger J., Milas A., Šumanovac Šestak I., Risteski P., Cojoc G., Roscioli E., Welburn J., Cimini D., Glunčić M., Pavin N., Tolić IM. Overlap microtubules link sister k-fibers and balance the forces on bioriented kinetochores. Nat Communications. 7 (2016) 


 

Cell Scientist to Watch- Julie Welburn (2015). 128(4465-4466). Journal of Cell Science.


Anna A. Ye, Jovana Deretic, Christopher M. Hoel, Albert W. Hinman, Daniela Cimini, Julie P. Welburn, Thomas J. Maresca. Aurora A Kinase Contributes to a Pole-Based Error Correction Pathway. Current Biology. (2015).


structure talapatra

Talapatra S., Harker B., Welburn JPI.  The C-terminal region of the motor protein MCAK controls its activity and structure through a major conformational switch. Elife. (2015)


Young S., Besson S., Welburn JPI. Analysis of microtubule dynamic regulators highlights length-dependent anisotropic scaling of spindle shape. Biology Open. (2014). 3:1217-1223. 

Welburn J.P. The molecular basis for kinesin functional specificity during mitosis. Cytoskeleton (2013). [PubMed]

Syred HM,  Welburn J.P., Rappsilber J, Ohkura H. Cell cycle regulation of microtubule interactomes: multi-layered regulation is critical for the interphase/mitosis transition Mol Cell Proteomics (2013). [PubMed]

Welburn J.P.I. & Cheeseman I.M. The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle Mol Biol Cell (2012).  [PubMed]

Welburn J.P.I., Vleugel M., Liu D., Yates III J.R., Lampson M.A., Fukagawa T., Cheeseman I.M. Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface.  Mol Cell (2010). 38: 383-92.  [PubMed]

Welburn J.P.I., Grishchuk E.L., Backer C.B., Wilson-Kubalek, E.M., Yates III J.R., and Cheeseman I.M. The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. Dev Cell (2009). 16: 374-385. [PubMed]

Welburn J.P.I. and Cheeseman I. M. Towards a Molecular Structure of the Eukaryotic Kinetochore. Dev. Cell (2008). 15: 645-655. [PubMed]

 

Hori T., Amano M., Suzuki A., Backer C. B., Welburn J.P.I., Dong Y., McEwen B. F., Shang W-H., Suzuki E., Okawa K., Cheeseman I. M. and Fukagawa T. The Constitutive Centromere Associated Network makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore. Cell (2008). 135:1039-52. [PubMed]

Wang H.-W., Ramey V., Westermann S., Leschziner A., Welburn J.P.I., Nakajima Y., Drubin D., Barnes G. and Nogales E. Architecture and microtubule-driven assembly of the Dam1 kinetochore ring complex. Nat Struct Mol Biol. (2007). 14: 721-6. [PubMed]

Welburn J.P.I., Tucker J., Johnson T., Morgan M., Noble M. and Endicott J. How tyrosine 15 phosphorylation inhibits the activity of CDK2/cyclin A. J Biol Chem. (2007). 282: 3173-81. [PubMed]

mol cell

*Macdonald N., *Welburn J.P.I., Noble M., Endicott J., Nguyen, Yaffe M., Clynes D., Moggs J., Orphanides G., Thomson S., Edmunds J. and Mahadevan L.C. Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3. Molecular Cell (2005). 20: 199-211. * equal contribution to the paper. [PubMed]

 

 

 

Welburn J.P.I., Endicott J. Cell cycle inhibition: a targeted approach.Seminars in Cell and Developmental Biology (2005). 16, 369-381. [PubMed]

Welburn J.P.I., Endicott J. Methods for preparation of proteins and protein complexes that regulate the eukaryotic cell cycle for structural studies. Methods Mol Biol. (2004). 296:219-36. [PubMed]